MCU Mouse Monoclonal Antibody [A2E11] — image 1 of 2

Product details

MCU Mouse Monoclonal Antibody [A2E11]

Catalog number EM1901-85

Price for EM1901-85

Size / count 100 µL

About this product

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca (2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca (2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.

Specifications

Catalog number: EM1901-85
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: C109A_HUMAN antibody C10orf42 antibody Calcium uniporter protein mitochondrial antibody Ccdc109a antibody Coiled-coil domain-containing protein 109A antibody HsMCU antibody Mitochondrial Calcium Uniporter antibody
Abbreviation: MCU
Swiss Prot: Q8NE86 Human, Q3UMR5 Mouse,
Cellular Locus: Mitochondrion.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human MCU aa 51-325 / 351.
Isotype: IgM
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB
Positive Control: 293 cell lysates, A549.
Concentration: 2 mg/mL
Dilution: WB:1:500-1:1,000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size 40 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for MCU Mouse Monoclonal Antibody [A2E11]?

The catalog number for MCU Mouse Monoclonal Antibody [A2E11] is EM1901-85.

What sizes are available for MCU Mouse Monoclonal Antibody [A2E11]?

MCU Mouse Monoclonal Antibody [A2E11] is available in the following size(s): 100 µL.

Is MCU Mouse Monoclonal Antibody [A2E11] in stock?

MCU Mouse Monoclonal Antibody [A2E11] is currently made to order / not held in immediate stock. Contact us for lead time.

What is MCU Mouse Monoclonal Antibody [A2E11] used for?

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.