Caveolin-1 Mouse Monoclonal Antibody [A3E8]

About this product

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. Caveolin 1 has been shown to interact with heterotrimeric G proteins, Src tyrosine kinases (Src, Lyn) and H-Ras, cholesterol, TGF beta receptor 1, endothelial NOS, androgen receptor, amyloid precursor protein, gap junction protein, alpha 1, nitric oxide synthase 2A, epidermal growth factor receptor, endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2, PLD2, Bruton's tyrosine kinase and SCP2. All these interactions are through a caveolin-scaffolding domain (CSD) within caveolin-1 molecule. Molecules that interact with caveolin-1 contain caveolin-binding motifs (CBM).

Specifications

Catalog number

EM1901-88

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

BSCL3 antibody CAV antibody CAV1 antibody CAV1_HUMAN antibody caveolae protein, 22 kD antibody caveolin 1 alpha isoform antibody caveolin 1 beta isoform antibody Caveolin 1 caveolae protein 22kDa antibody Caveolin-1 antibody Caveolin1 antibody cell growth-inhibiting protein 32 antibody CGL3 antibody LCCNS antibody MSTP085 antibody OTTHUMP00000025031 antibody PPH3 antibody VIP 21 antibody VIP21 antibody

Abbreviation

CAV1

Swiss Prot

Q03135 Human

Cellular Locus

Cell membrane, golgi apparatus membrane, trans-golgi network, caveola, membrane raft.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human Caveolin-1 aa 1-150.

Isotype

IgG2b

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SiHa cell lysates, SKOV-3, human liver tissue, human lung tissue, human lung carcinoma tissue, PANC-1.

Concentration

2 mg/mL

Dilution

WB:1:500-1:2,000;IF-Cell:1:50-1:100;IHC-P:1:500-1:2,000;FC:1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

20 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No