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Product details

CD68 Mouse Monoclonal Antibody [A3C4]

Catalog number EM1901-95

Price for EM1901-95

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Size / count 100 µL

About this product

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). Human CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a molecular weight of 110 kD. Its primary sequence consists of 354 amino acids with predicted molecular weight of 37.4 kD if it were not glycosylated. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells and myocytes. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease. Anti-CD68 monoclonal antibodies that react with tissues of rodent and other species include ED1, FA-11, KP1 (a.k.a. C68/684), 6A326, 6F3, 12E2, 10B1909, and SPM130. Monoclonals that react with humans include, Ki-M7, PG-M1, 514H12, ABM53F5, 3F7C6, 3F7D3, Y1/82A, EPR20545, CDLA68-1, LAMP4-824.

Specifications

Catalog number
EM1901-95
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Product Name Alternative
CD 68 antibody CD68 antibody CD68 antigen antibody CD68 molecule antibody CD68_HUMAN antibody DKFZp686M18236 antibody gp11 antibody Gp110 antibody LAMP4 antibody Macrophage antigen CD68 (microsialin) antibody MACROPHAGE ANTIGEN CD68 antibody Macrosialin antibody SCARD1 antibody Scavenger receptor class D member 1 antibody
Abbreviation
CD68
Swiss Prot
P34810 Human
Cellular Locus
Cell membrane. Endosome membrane, lysosome membrane.
Host
Mouse
Species Reactivity
Human
Immunogen
Synthetic peptide within human CD68 aa 320-354.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, FC, mIHC
Positive Control
A431 cell lysate, THP-1 cell lysate, U-937 cell lysate, human tonsil tissue, human lung tissue, THP-1, human pancreatic carcinoma.
Concentration
2 mg/mL
Dilution
WB:1:1,000-1:2,000 ;IHC-P:1:200-1:1,000 ;FC:1:1,000 ;mIHC: 1:3,000
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

Frequently Asked Questions

What is the catalog number for CD68 Mouse Monoclonal Antibody [A3C4]?

The catalog number for CD68 Mouse Monoclonal Antibody [A3C4] is EM1901-95.

What sizes are available for CD68 Mouse Monoclonal Antibody [A3C4]?

CD68 Mouse Monoclonal Antibody [A3C4] is available in the following size(s): 100 µL.

Is CD68 Mouse Monoclonal Antibody [A3C4] in stock?

CD68 Mouse Monoclonal Antibody [A3C4] is currently made to order / not held in immediate stock. Contact us for lead time.

What is CD68 Mouse Monoclonal Antibody [A3C4] used for?

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). Human CD68 is a transmembrane glycoprotein, heavily glycosylated in i

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

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