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Product details

Caspr Mouse Monoclonal Antibody [A2D2]

Catalog number EM1902-10

Price for EM1902-10

Size / count 100 µL

About this product

CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon[[]] in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels. During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet understood. The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Specifications

Catalog number: EM1902-10
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Caspr antibody Caspr1 antibody CNTNAP antibody Cntnap1 antibody CNTP1_HUMAN antibody Contactin associated protein 1 antibody Contactin-associated protein 1 antibody MHDNIV antibody NCP1 antibody Neurexin 4 antibody Neurexin IV antibody Neurexin-4 antibody Nrxn4 antibody p190 antibody Paranodin antibody
Abbreviation: CNTNAP1
Swiss Prot: P78357 Human, O54991 Mouse
Cellular Locus: Membrane, paranodal septate junction.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within human Caspr aa 1100-1300.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: IHC-P, FC
Positive Control: Human kidney tissue, mouse kidney tissue, SH-SY5Y.
Concentration: 2 mg/mL
Dilution: IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 156 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Caspr Mouse Monoclonal Antibody [A2D2]?

The catalog number for Caspr Mouse Monoclonal Antibody [A2D2] is EM1902-10.

What sizes are available for Caspr Mouse Monoclonal Antibody [A2D2]?

Caspr Mouse Monoclonal Antibody [A2D2] is available in the following size(s): 100 µL.

Is Caspr Mouse Monoclonal Antibody [A2D2] in stock?

Caspr Mouse Monoclonal Antibody [A2D2] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Caspr Mouse Monoclonal Antibody [A2D2] used for?

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.