COX2 Mouse Monoclonal Antibody [A3F7]

About this product

Cytochrome c oxidase subunit 2, also known as cytochrome c oxidase polypeptide II, is a protein that in humans is encoded by the MT-CO2 gene. Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV. The MT-CO2 gene is located on the p arm of mitochondrial DNA at position 12 and it spans 683 base pairs.[5] The MT-CO2 gene produces a 25.6 kDa protein composed of 227 amino acids.MT-CO2 is a subunit of the enzyme Cytochrome c oxidase (EC 1.9.3.1) (Complex IV), an oligomeric enzymatic complex of the mitochondrial respiratory chain involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices. The structure of MT-CO2 is known to contain one redox center and a binuclear copper A center (CuA). The CuA is located in a conserved cysteine loop at 196 and 200 amino acid positions and conserved histidine at 204. Several bacterial MT-CO2 have a C-terminal extension that contains a covalently bound haem c.

Specifications

Catalog number

EM1902-12

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

COX 2 antibody COX-2 antibody COX2 antibody Cyclooxygenase 2 antibody Cyclooxygenase 2b antibody Cyclooxygenase antibody Cyclooxygenase-2 antibody Cyclooxygenase2 antibody EC 1.14.99.1 antibody fj02a10 antibody Glucocorticoid-regulated inflammatory cyclooxygenase antibody Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody GRIPGHS antibody hCox 2 antibody Macrophage activation-associated marker protein P71/73 antibody OTTHUMP00000033524 antibody PES-2 antibody PGG/HS antibody PGH synthase 2 antibody PGH2_HUMAN antibody PGHS 2 antibody PGHS-2 antibody PGHS2 antibody PHS 2 antibody PHS II antibody PHS2 antibody Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody Prostaglandin endoperoxide synthase 2 antibody Prostaglandin G/H synthase 2 antibody Prostaglandin G/H synthase 2 precursor antibody Prostaglandin G/H synthase and cyclooxygenase antibody Prostaglandin G/H synthase antibody Prostaglandin H2 synthase 2 antibody prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody Prostaglandin-endoperoxide synthase 2 antibody PTGS2 antibody ptgs2a antibody TIS10 antibody TIS10 protein antibody unp1239 antibody wu:fj02a10 antibody

Abbreviation

PTGS2

Swiss Prot

P35354 Human, P35355 Rat

Cellular Locus

Microsome membrane, endoplasmic reticulum membrane.

Host

Mouse

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within C-terminal of human COX2.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

A549 cell lysates, Hela cell lysates, rat spinal cord tissue lysates ,rat bladder tissue, human lung carcinoma tissue, human womb tissue, A549.

Concentration

2 mg/mL

Dilution

WB:1:500 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 69 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No