APOER2 Mouse Monoclonal Antibody [13B2] — image 1 of 2

Product details

APOER2 Mouse Monoclonal Antibody [13B2]

Catalog number EM1902-30

Price for EM1902-30

Size / count 100 µL

About this product

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).

Specifications

Catalog number: EM1902-30
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: APOER2 antibody Apolipoprotein E receptor 2 antibody low density lipoprotein receptor-related protein 8 antibody Low-density lipoprotein receptor-related protein 8 antibody LRP-8 antibody LRP8 antibody LRP8_HUMAN antibody
Abbreviation: Low-density lipoprotein receptor-related protein 8,LRP-8,Apolipoprotein E receptor 2,LRP8
Swiss Prot: Q14114 Human
Cellular Locus: Cell membrane, Secreted.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human APOER2 aa 47-275 / 963.
Isotype: IgG2a
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P
Positive Control: A549 cell lysate, SHSY5Y cell lysate, SKBR-3 cell lysate, U937 cell lysate, Hela, A549, human testis tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:400
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 106 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for APOER2 Mouse Monoclonal Antibody [13B2]?

The catalog number for APOER2 Mouse Monoclonal Antibody [13B2] is EM1902-30.

What sizes are available for APOER2 Mouse Monoclonal Antibody [13B2]?

APOER2 Mouse Monoclonal Antibody [13B2] is available in the following size(s): 100 µL.

Is APOER2 Mouse Monoclonal Antibody [13B2] in stock?

APOER2 Mouse Monoclonal Antibody [13B2] is currently made to order / not held in immediate stock. Contact us for lead time.

What is APOER2 Mouse Monoclonal Antibody [13B2] used for?

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.