YKL-40/CHI3L1 Mouse Monoclonal Antibody [A3G10]

About this product

Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells, vascular smooth muscle cells, and hepatic stellate cells. The biological function of YKL-40 is unclear. It is not known to have a specific receptor. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas and asthma. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. YKL-40 lacks chitinase activity due to mutations within the active site.

Specifications

Catalog number

EM1902-31

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

39 kDa synovial protein antibody ASRT7 antibody Cartilage glycoprotein 39 antibody CGP-39 antibody CGP39 antibody CH3L1_HUMAN antibody CHI3L1 antibody chitinase 3 like 1 (cartilage glycoprotein 39) antibody chitinase 3 like 1 antibody Chitinase 3 like protein 1 precursor antibody chitinase antibody Chitinase-3-like protein 1 antibody Chondrocyte protein YKL40 antibody GP 39 antibody GP-39 antibody GP39 antibody HC gp39 antibody HCGP 3P antibody hCGP-39 antibody HCgp39 antibody YKL 40 antibody YKL-40 antibody YKL40 antibody YYL 40 antibody

Abbreviation

CHI3L1

Swiss Prot

P36222 Human

Cellular Locus

Extracellular space, Endoplasmic reticulum, Cytoplasm.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within extracellular domain of Human CHI3L1.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

THP-1 cell lysates, human tonsil tissue.

Concentration

2 mg/mL

Dilution

WB:1:500-1:2,000 ;IHC-P:1:50-1:200

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No