Myc tag Mouse Monoclonal Antibody [A3C8]

About this product

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis . Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). Myc is thought to function by upregulating transcript elongation of actively transcribed genes through the recruitment of elongation factors.[8] It can also act as a transcriptional repressor. By binding Miz-1 transcription factor and displacing the p300 co-activator, it inhibits expression of Miz-1 target genes. In addition, myc has a direct role in the control of DNA replication.[9] This activity could contribute to DNA amplification in cancer cells.

Specifications

Catalog number

EM1902-38

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AU016757 antibody Avian myelocytomatosis viral oncogene homolog antibody bHLHe39 antibody c Myc antibody Cellular myelocytomatosis oncogene antibody Class E basic helix-loop-helix protein 39 antibody MGC105490 antibody MRTL antibody Myc antibody Myc protein antibody Myc proto oncogene protein antibody Myc proto-oncogene protein antibody myc-related translation/localization regulatory factor antibody MYC_HUMAN antibody Myc2 antibody myca antibody MYCC antibody Myelocytomatosis oncogene a antibody Myelocytomatosis oncogene antibody Niard antibody Nird antibody oncogene c-Myc antibody Oncogene Myc antibody OTTHUMP00000158589 antibody OTTHUMP00000227763 antibody Proto-oncogene c-Myc antibody Protooncogene homologous to myelocytomatosis virus antibody RNCMYC antibody Transcription factor p64 antibody Transcriptional regulator Myc-A antibody V-Myc avian myelocytomatosis viral oncogene homolog antibody v-myc myelocytomatosis viral oncogene homolog (avian) antibody zc-myc antibody

Abbreviation

Myc proto-oncogene protein,MYC

Host

Mouse

Species Reactivity

Universal

Immunogen

Synthetic peptide EQKLISEEDL conjugated to keyhole limpet haemocyanin.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, ELISA, IP

Positive Control

C-terminal Myc-tagged recombinant protein lysates, N-terminal Myc-tagged recombinant protein lysates.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;ELISA: Use at an assay dependent concentration. ;IP: 2-5 µg/ml.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No