CELF2 Mouse Monoclonal Antibody [D7-B5]

About this product

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5.

Specifications

Catalog number

EM1902-41

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Bruno-like protein 3 antibody BRUNOL3 antibody Cardiac elav type RNA binding protein antibody CELF-2 antibody celf2 antibody CELF2_HUMAN antibody CUG BP2 antibody CUG triplet repeat RNA-binding protein 2 antibody CUG-BP- and ETR-3-like factor 2 antibody CUG-BP2 antibody CUGBP Elav like family member 2 antibody CUGBP Elav-like family member 2 antibody CUGBP2 antibody dJ323N1.1 antibody elav type RNA binding protein antibody ELAV-type RNA-binding protein 3 antibody ETR 3 antibody ETR-3 antibody ETR3 antibody HGNC:2550 antibody hNAPOR antibody NAPOR 2 antibody NAPOR antibody Neuroblastoma apoptosis-related RNA-binding protein antibody Neuroplastoma apoptosis related RNA binding protein 3 antibody RNA binding protein BRUNOL3 antibody RNA-binding protein BRUNOL-3 antibody

Abbreviation

CUGBP Elav-like family member 2,CELF-2,Bruno-like protein 3 CUG triplet repeat RNA-binding protein 2 CUG-BP2 CUG-BP- and ETR-3-like factor 2 ELAV-type RNA-binding protein 3 ETR-3 Neuroblastoma apoptosis-related RNA-binding protein hNAPOR RNA-binding protein BRUNOL-3

Swiss Prot

O95319 Human, Q9Z0H4 Mouse, Q792H5 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CELF2 aa 450-508.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

MCF-7 cell lysate, A549 cell lysate, PC-3M cell lysate, rat brain tissue, mouse brain tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:100-1:500

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No