MAPK14 Mouse Monoclonal Antibody [9-B9]

About this product

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response.

Specifications

Catalog number

EM40307

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CSAID Binding Protein 1 antibody CSAID binding protein antibody CSAID-binding protein antibody Csaids binding protein antibody CSBP 1 antibody CSBP 2 antibody CSBP antibody CSBP1 antibody CSBP2 antibody CSPB1 antibody Cytokine suppressive anti-inflammatory drug-binding protein antibody EXIP antibody MAP kinase 14 antibody MAP kinase MXI2 antibody MAP kinase p38 alpha antibody MAPK 14 antibody MAPK14 antibody MAX interacting protein 2 antibody MAX-interacting protein 2 antibody Mitogen Activated Protein Kinase 14 antibody Mitogen activated protein kinase p38 alpha antibody Mitogen-activated protein kinase 14 antibody Mitogen-activated protein kinase p38 alpha antibody MK14_HUMAN antibody Mxi 2 antibody MXI2 antibody p38 ALPHA antibody p38 antibody p38 MAP kinase antibody p38 MAPK antibody p38 mitogen activated protein kinase antibody p38ALPHA antibody p38alpha Exip antibody PRKM14 antibody PRKM15 antibody RK antibody SAPK2A antibody

Abbreviation

MAP kinase 14,MAPK 14,CSAID-binding protein,CSBP,MAP kinase p38 alpha,SAPK2a

Swiss Prot

Q16539 Human, P47811 Mouse

Cellular Locus

Cytoplasm, nucleus

Host

Mouse

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human MAPK14 aa 1-50 / 360.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HepG2 cell lysates, A431 cell lysates, NIH/3T3 cell lysates, Hela cell lysates, Jurkat cell lysates, 293T cell lysates, mouse placenta tissue lysates, Hela, human colon carcinoma tissue,human stomach carcinoma tissue, mouse stomach tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:100-1:200;IHC-P: 1:100-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No