HER2 / ErbB2 Rabbit Polyclonal Antibody

About this product

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients. Over-expression is also known to occur in ovarian, stomach, and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2. However, when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.

Specifications

Catalog number

ER0106

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody C erb B2/neu protein antibody CD340 antibody CD340 antigen antibody Cerb B2/neu protein antibody CerbB2 antibody Erb b2 receptor tyrosine kinase 2 antibody ERBB2 antibody ERBB2_HUMAN antibody HER 2 antibody HER 2/NEU antibody HER2 antibody Herstatin antibody Human epidermal growth factor receptor 2 antibody Metastatic lymph node gene 19 protein antibody MLN 19 antibody MLN19 antibody NEU antibody NEU proto oncogene antibody Neuro/glioblastoma derived oncogene homolog antibody Neuroblastoma/glioblastoma derived oncogene homolog antibody NGL antibody p185erbB2 antibody Proto-oncogene c-ErbB-2 antibody Proto-oncogene Neu antibody Receptor tyrosine-protein kinase erbB-2 antibody TKR1 antibody Tyrosine kinase type cell surface receptor HER2 antibody Tyrosine kinase-type cell surface receptor HER2 antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

Abbreviation

MLN 19

Swiss Prot

P04626 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human HER2 aa 1-50 / 1,255.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

SK-Br-3 cell lysate, SKOV-3 cell lysate, 4T1 cell lysate, human breast cancer tissue, human stomach carcinoma tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 138 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No