LGR5 Rabbit Polyclonal Antibody

About this product

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Specifications

Catalog number

ER10708

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

FEX antibody G protein coupled receptor 49 antibody G protein coupled receptor 67 antibody g protein-coupled receptor fex antibody G-protein coupled receptor 49 antibody G-protein coupled receptor 67 antibody G-protein coupled receptor HG38 antibody GPR 49 antibody GPR 67 antibody GPR49 antibody GPR67 antibody GRP 49 antibody GRP49 antibody HG 38 antibody HG38 antibody Leucine rich repeat containing G protein coupled receptor 5 antibody Leucine-rich repeat-containing G-protein coupled receptor 5 antibody LGR 5 antibody LGR5 antibody LGR5_HUMAN antibody MGC117008 antibody Orphan G protein coupled receptor HG38 antibody

Abbreviation

LGR5,GPR49, GPR67

Swiss Prot

O75473 Human, Q9Z1P4 Mouse,

Cellular Locus

Cytoplasm, cell membrane, Golgi apparatus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Mouse GPR49 / LGR5 alpha / beta aa 1-50 / 907 (ID: Q9Z1P4).

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB

Positive Control

Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, F9 cell lysate, Hela cell lysate, K562 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 100 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No