NOX2/gp91phox Rabbit Polyclonal Antibody

About this product

Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutro-phils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.

Specifications

Catalog number

ER1511-34

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AMCBX2 antibody CGD antibody CGD91-phox antibody CY24B_HUMAN antibody CYBB antibody Cytochrome b 245, beta polypeptide antibody Cytochrome b (558) beta chain antibody Cytochrome b (558) subunit beta antibody Cytochrome b-245 heavy chain antibody Cytochrome b558 subunit beta antibody GP91 PHOX antibody gp91-1 antibody gp91-phox antibody GP91PHOX antibody Heme-binding membrane glycoprotein gp91phox antibody NADPH oxidase 2 antibody Neutrophil cytochrome b 91 kDa polypeptide antibody NOX2 antibody p22 phagocyte B-cytochrome antibody P91 PHOX antibody p91-PHOX antibody Superoxide-generating NADPH oxidase heavy chain subunit antibody

Abbreviation

Cytochrome b558 subunit beta, CYBB, NOX2

Swiss Prot

P04839 Human, Q61093 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to C-terminal human NOX2/gp91phox.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

IF-Cell, IHC-P, FC

Positive Control

HepG2, MCF-7, Hela, human liver tissue, human spleen tissue, human tonsil tissue, mouse spleen tissue.

Concentration

1 mg/mL

Dilution

IF-Cell: 1:50-1:200;IHC-P: 1:500-1:1,000;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 65 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No