DKK1 Rabbit Polyclonal Antibody — image 1 of 3

Product details

DKK1 Rabbit Polyclonal Antibody

Catalog number ER1512-20

Price for ER1512-20

Size / count 100 µL

About this product

The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the seven membrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-catenin and subsequent regulation of developmentally significant Wnt |target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of the Wnt cascade. Dkk-1 (Dickkopf-1) acts upstream of b-catenin and dishevelled to inhibit Wnt signaling. Dkk-1 is a 266-amino acid (human), secreted protein that contains a 31-residue N-terminal signal peptide, 2 cysteine rich domains, and a putative carboxy terminal N-glycosylation site. Human Dkk-1 transcripts are abundantly present in fetal kidney, adult placenta and adult prostate. Putative cis regulatory elements upstream of the Dkk-1 start site include p53, Sp1, MyoD, STAT, Oct-1/2, C/EBP-a, C/EBP-b, GATA-1, GATA-2 and GATA-3.

Specifications

Catalog number: ER1512-20
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Dickkopf 1 antibody Dickkopf 1 homolog antibody Dickkopf 1 like antibody Dickkopf homolog 1 antibody Dickkopf like protein 1 antibody Dickkopf related protein 1 antibody Dickkopf WNT signaling pathway inhibitor 1 antibody Dickkopf-1 antibody Dickkopf-related protein 1 antibody DKK 1 antibody Dkk-1 antibody Dkk1 antibody DKK1_HUMAN antibody hDkk 1 antibody hDkk-1 antibody SK antibody
Abbreviation: Dickkopf-1, Dkk-1, hDkk-1
Swiss Prot: O94907 Human, O54908 Mouse
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic peptide within C-terminal human DKK1.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: Mouse brain tissue lysate, human fetal brain tissue lysate, Hela, NCCIT, human placenta tissue, mouse placenta tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 29 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for DKK1 Rabbit Polyclonal Antibody?

The catalog number for DKK1 Rabbit Polyclonal Antibody is ER1512-20.

What sizes are available for DKK1 Rabbit Polyclonal Antibody?

DKK1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is DKK1 Rabbit Polyclonal Antibody in stock?

DKK1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is DKK1 Rabbit Polyclonal Antibody used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.