PRTN3 Rabbit Polyclonal Antibody

About this product

The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.

Specifications

Catalog number

ER1706-25

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ACPA antibody AGP 7 antibody AGP7 antibody AGP7 serine proteinase antibody Azurophil Granule Protein 7 antibody C ANCA antibody C ANCA antigen antibody C-ANCA antigen antibody CANCA antibody EC 3.4.21.76 antibody Leukocyte proteinase 3 antibody MBN antibody MBT antibody MBT WEGENER AUTOANTIGEN antibody Myeloblastin antibody Neutrophil proteinase 4 antibody NP 4 antibody NP-4 antibody NP4 antibody P29 antibody PR 3 antibody PR-3 antibody PR3 antibody Proteinase 3 antibody Proteinase3 antibody PRTN 3 antibody Prtn3 antibody PRTN3_HUMAN antibody Serine proteinase neutrophil Wegener granulomatosis autoantigen antibody Serine proteinase, neutrophil antibody Wegener autoantigen antibody Wegener granulomatosis autoantigen antibody

Abbreviation

PR-3, PR3, NP-4, PRTN3, MBN

Swiss Prot

P24158 Human, Q61096 Mouse

Cellular Locus

Cytoplasmic granule, Secreted, Cell membrane, Membrane raft.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human PRTN3 aa 50-248 / 256.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

U937, mouse marrow lysate, 293T, A549, SH-SY5Y, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 28 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No