PPM1A Rabbit Polyclonal Antibody

About this product

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/ threonine protein phosphatases. Protein phosphatase 2Ca (PP2Ca) has broad specificity. It dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase-kinases while also inhibiting the activation of p38 and JNK kinase cascades, induced by environmental stresses. PP2Ca also induces the expression of endogenous p53 and the p53-responsive gene p21, leading to cell cycle arrest and apoptosis. The PP2Ca protein, which contains an active site containing a dinuclear metal ion center, shows highest expression in epithelial cells, as well as in the digestive tract, lung, kidney, breast, prostate, endocrine glands and brain.

Specifications

Catalog number

ER1706-37

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Protein phosphatase 2C isoform alpha antibody EC 3.1.3.16 antibody FLJ42306 antibody IA antibody MGC9201 antibody Mpp alpha antibody PP2C alpha antibody PP2C-alpha antibody PP2CA antibody PP2Calpha antibody PPM 1A antibody PPM1A antibody PPM1A_HUMAN antibody PPPM1A antibody Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform antibody Protein phosphatase 1A antibody Protein phosphatase 1A magnesium dependent alpha antibody Protein phosphatase 2C alpha antibody Protein phosphatase 2C alpha isoform antibody Protein phosphatase 2C isoform alpha antibody Protein phosphatase IA antibody Protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody

Abbreviation

PP2C-alpha, PPM1A, PPPM1A

Swiss Prot

P35813 Human, P49443 Mouse, P20650 Rat

Cellular Locus

Cytoplasm, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human PP2C alpha aa 42-330 / 382.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Mouse kidney tissue lysate, rat skin tissue lysate, A431, A549, SH-SY5Y, human kidney tissue, human colon cancer tissue, mouse intestine tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

42/35 kDa, additional band 55 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No