Superoxide Dismutase 1 Rabbit Polyclonal Antibody

About this product

Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer's disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Specifications

Catalog number

ER1706-49

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ALS antibody ALS1 antibody Amyotrophic lateral sclerosis 1 adult antibody Cu/Zn SOD antibody Cu/Zn superoxide dismutase antibody Epididymis secretory protein Li 44 antibody HEL S 44 antibody Homodimer antibody hSod1 antibody Indophenoloxidase A antibody IPOA antibody Mn superoxide dismutase antibody SOD antibody SOD soluble antibody SOD1 antibody SOD2 antibody SODC antibody SODC_HUMAN antibody Superoxide dismutase [Cu-Zn] antibody Superoxide dismutase 1 antibody Superoxide dismutase 1 soluble antibody Superoxide dismutase Cu Zn antibody Superoxide dismutase cystolic antibody

Abbreviation

hSod1, SOD1

Swiss Prot

P00441 Human, P08228 Mouse, P07632 Rat

Cellular Locus

Cytoplasm, Mitochondrion, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human SOD1 aa 6-154.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

MCF7 cell lysate, HepG2 cell lysate, HUVEC cell lysate, SH-SY5Y cell lysate, human liver tissue lysate, HepG2, LOVO, MCF-7.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:500-1:2,000 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 16 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No