LOX-1 Rabbit Polyclonal Antibody

About this product

The oxidized low density lipoprotein (lectin-like) receptor-1, Ox-LDL R-1, is a type II membrane protein that is a member of the C-type lectin family and acts as a cell-surface receptor for oxidized low density lipoprotein (Ox-LDL). Ox-LDL plays a role in early atherosclerosis, which includes the transformation of monocyte-derived macrophages to foam cells in atherosclerotic lesions. The binding of Ox-LDL to Ox-LDL R-1 may also trigger the activation of the NFkB signal transduction pathway. Ox-LDL R-1, also designated scavenger receptor class E, member 1 (SCARE1); lectin-type oxidized LDL receptor 1 (LOX-1); and CLEC8A), is expressed by vascular endothelial cells, smooth muscle cells and macrophages. It is expressed endogenously as a precursor form with N-linked high mannose carbohydrate chains and as a mature form due to further glycosylation. The N-linked glycosylation of Ox-LDL R-1 appears to be necessary for adequate transportation to the cell surface and efficient ligand binding.

Specifications

Catalog number

ER1706-53

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C-type lectin domain family 8 member A antibody CLEC8A antibody hLOX 1 antibody hLOX-1 antibody Lectin like oxidized LDL receptor 1 antibody Lectin like oxLDL receptor 1 antibody Lectin type oxidized LDL receptor 1 antibody Lectin-like oxidized LDL receptor 1 antibody Lectin-like oxLDL receptor 1 antibody Lectin-type oxidized LDL receptor 1 antibody low density lipoprotein oxidized, receptor 1 antibody LOX-1 antibody LOXIN antibody Olr1 antibody OLR1_HUMAN antibody Ox LDL receptor 1 antibody Ox-LDL receptor 1 antibody Oxidised low density lipoprotein (lectin like) receptor 1 antibody Oxidized low density lipoprotein receptor 1 antibody Oxidized low density lipoprotein receptor 1 soluble form antibody Oxidized low-density lipoprotein receptor 1 antibody SCARE1 antibody Scavenger receptor class E, member 1 antibody SLOX1 antibody soluble form antibody SR-EI antibody

Abbreviation

Ox-LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, OLR1, CLEC8A, LOX1

Swiss Prot

P78380 Human, Q9EQ09 Mouse

Cellular Locus

Cell membrane. Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human LOX-1 aa 17-273 / 273.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

MCF-7 cell lysates, human lung tissue lysates, human kidney tissue, human placenta tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:200-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No