BMAL1 Rabbit Polyclonal Antibody

About this product

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or brain and muscle ARNT-Like 1 (BMAL1) is a protein that in humans is encoded by the ARNTL gene, also known as BMAL1, MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC. ARNTL encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome.[4] The ARNTL protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian auto-regulatory transcription-translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. Research has revealed that ARNTL is the only clock gene without which the circadian clock fails to function in humans. ARNTL has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in ARNTL have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. ARNTL, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

Specifications

Catalog number

ER1706-71

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ARNT like protein 1 brain and muscle antibody Arntl antibody Aryl hydrocarbon receptor nuclear translocator like antibody Aryl hydrocarbon receptor nuclear translocator like protein 1 antibody Aryl hydrocarbon receptor nuclear translocator-like protein 1 antibody Basic helix loop helix PAS orphan MOP3 antibody Basic helix loop helix PAS protein MOP3 antibody Basic-helix-loop-helix-PAS protein MOP3 antibody bHLH PAS protein JAP3 antibody bHLH-PAS protein JAP3 antibody bHLHe5 antibody BMAL 1 antibody BMAL1_HUMAN antibody BMAL1c antibody Brain and muscle ARNT like 1 antibody Brain and muscle ARNT-like 1 antibody CG8727 PA antibody Class E basic helix-loop-helix protein 5 antibody cycle antibody JAP 3 antibody JAP3 antibody Member of PAS protein 3 antibody Member of PAS superfamily 3 antibody MGC47515 antibody MOP 3 antibody MOP3 antibody PAS domain-containing protein 3 antibody PASD 3 antibody PASD3 antibody TIC antibody

Abbreviation

bHLHe5, ARNTL, BHLHE5, BMAL1, MOP3, PASD3

Swiss Prot

O00327 Human, Q9WTL8 Mouse, Q9EPW1 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within N-terminal human BMAL1.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SYSH5Y cell lysates, A549, MCF-7, human liver cncer tissue, human prostate tissue, mouse brain tissue, mouse prostate tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-2,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 69 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No