NLRP3 Rabbit Polyclonal Antibody

About this product

NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases. Cryopyrin interacts selectively with apoptosis associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Specifications

Catalog number

ER1706-72

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

Product Name Alternative

AGTAVPRL antibody AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like antibody Angiotensin/vasopressin receptor AII/AVP-like antibody C1orf7 antibody Caterpiller protein 1.1 antibody CIAS 1 antibody CIAS1 antibody CLR1.1 antibody Cold autoinflammatory syndrome 1 antibody Cold autoinflammatory syndrome 1 protein antibody Cryopyrin antibody Familial cold autoinflammatory syndrome antibody FCAS antibody FCU antibody LRR and PYD domains-containing protein 3 antibody Muckle-Wells syndrome antibody MWS antibody NACHT antibody NACHT LRR and PYD containing protein 3 antibody NALP 3 antibody NALP3 antibody NALP3_HUMAN antibody NLR family pyrin domain containing 3 antibody NLRP3 antibody PYPAF 1 antibody PYPAF1 antibody PYRIN containing APAF1 like protein 1 antibody PYRIN-containing APAF1-like protein 1 antibody

Abbreviation

CLR1.1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Swiss Prot

Q96P20 Human, Q8R4B8 Mouse

Cellular Locus

Nucleus. Cytoplasm. Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human NLRP3 aa 987-1,036 / 1,036.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

LOVO cell lysate, A431, HepG2, LOVO, human liver cancer tissue, human colon cancer tissue, human placenta tissue, mouse brain tissue, mouse kidney tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:500-1:2,000;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 118 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No