RAR alpha Rabbit Polyclonal Antibody

About this product

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor that in humans is encoded by the RARA gene. NR1B1 is a gene with a protein product and has a chromosomal location of 17q21.2. RARA codes for the nuclear hormone receptor Retinoic Acid Receptor, Alpha subtype, and are themselves transcription factors. There are another 2 subtypes of RARs, Beta subtype, and Gamma subtype. Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery. Retinoic Acid Receptor Alpha, the protein, interacts with retinoic acid, a derivative of Vitamin A, which plays an important role in cell growth, differentiation, and the formation of organs in embryonic development. Once Retinoic Acid binds to the RAR, they initiate transcription and allow for their respective gene to be expressed.

Specifications

Catalog number

ER1706-81

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

NR1B1 antibody Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody Nuclear receptor subfamily 1 group B member 1 antibody Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody RAR alpha antibody RAR antibody RAR-alpha antibody rara antibody RARA_HUMAN antibody RARalpha antibody RARalpha1 antibody Retinoic acid nuclear receptor alpha variant 1 antibody Retinoic acid nuclear receptor alpha variant 2 antibody Retinoic acid receptor alpha antibody Retinoic acid receptor alpha polypeptide antibody

Abbreviation

RAR-alpha, RARA, NR1B1

Swiss Prot

P10276 Human, P11416 Mouse,

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human RAR alpha aa 135-406.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SK-Br-3 cell lysate, Hela cell lysate, A431, MCF-7, SH-SY5Y, rat brain tissue, mouse testis tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:500-1:2,000;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No