SHP-2 Rabbit Polyclonal Antibody

About this product

The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

Specifications

Catalog number

ER1706-93

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

BPTP3 antibody CFC antibody JMML antibody METCDS antibody MGC14433 antibody NS1 antibody OTTHUMP00000166107 antibody OTTHUMP00000166108 antibody Protein tyrosine phosphatase 2 antibody Protein tyrosine phosphatase 2C antibody Protein tyrosine phosphatase non receptor type 11 antibody Protein-tyrosine phosphatase 1D antibody Protein-tyrosine phosphatase 2C antibody PTN11_HUMAN antibody PTP-1D antibody PTP-2C antibody PTP1D antibody PTP2C antibody PTPN11 antibody SAP2 antibody SH-PTP2 antibody SH-PTP3 antibody SH2 domain containing protein tyrosine phosphatase 2 antibody SHP 2 antibody SHP-2 antibody Shp2 antibody SHPTP2 antibody SHPTP3 antibody Syp antibody Tyrosine-protein phosphatase non-receptor type 11 antibody

Abbreviation

PTP-1D, PTP-2C, SHP-2, Shp2, PTPN11, PTP2C, SHPTP2

Swiss Prot

Q06124 Human, P35235 Mouse, P41499 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human SHP-2 aa 359-575.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

IF-Cell, IHC-P, FC

Positive Control

A431, LOVO, MCF-7, rat skeletal muscle tissue, human colon cancer tissue, human fetal skeletal muscle tissue, mouse brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No