LSD1 Rabbit Polyclonal Antibody

About this product

Histone methylation regulates chromatin structure and transcription and maintains an epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases. Lysine-specific histone demethylase 1 (LSD1), also designated BHC110, is a flavin-dependent amine oxidase which catalyzes the removal of one or two methyl groups from the methyl-lysine-4 side chain of Histone H3. The LSD1 protein contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. Association with CoREST, a SANT domain-containing corepressor, positively regulates LSD1. CoREST mediates the demethylation ability of LSD1 and protects it from proteasomal degradation in vivo. PHF21A (also designated BCH80), a PHD domain-containing protein, inhibits activity of LSD1/CoREST mediated de-methylation. The LSD1 protein also co-localizes with the androgen receptor in human prostate tumor cells and in unaffected prostate cells, stimulating androgen-receptor-dependent transcription.

Specifications

Catalog number

ER1802-12

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Amine oxidase (flavin containing) domain 2 antibody Amine oxidase, flavin containing, 2 antibody AOF2 antibody BHC110 antibody BRAF35 HDAC complex protein BHC110 antibody BRAF35-HDAC complex protein BHC110 antibody BRAF35/HDAC complex, 110-kD subunit antibody CPRF antibody EC1 antibody FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody Flavin-containing amine oxidase domain-containing protein 2 antibody KDM 1 antibody KDM1 antibody Kdm1a antibody KDM1A_HUMAN antibody KIAA0601 antibody LSD 1 antibody LSD1 antibody Lysine (K) specific demethylase 1 antibody Lysine (K) specific demethylase 1A antibody Lysine demethylase 1A antibody Lysine specific histone demethylase 1 antibody Lysine specific histone demethylase 1A antibody Lysine-specific demethylase 1 antibody Lysine-specific demethylase 1A antibody Lysine-specific histone demethylase 1A antibody

Abbreviation

KDM1A, AOF2, KDM1, KIAA0601, LSD1

Swiss Prot

O60341 Human, Q6ZQ88 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within C-terminal human LSD1.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

PC-12 cell lysates, SiHa cell lysates, A431, HepG2, SH-SY-5Y, rat kidney tissue, human colon cancer tissue, human spleen tissue, human kidney tissue, mouse cerebellum tissue, K562.

Concentration

1 mg/mL

Dilution

WB: 1:500-1,000 ;IF-Cell: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 93 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No