CXCR4 Rabbit Polyclonal Antibody

About this product

The C-X-C or a chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemo-attractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB and CXCR-4 (also known as LESTR or fusin). CXCR-4 is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. CXCR-4 has been identified as the major co-receptor for T-tropic HIV-1 and SDF-1 has been shown to inhibit HIV-1 infection.

Specifications

Catalog number

ER1802-28

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

Product Name Alternative

C-X-C chemokine receptor type 4 antibody CD184 antibody CD184 antigen antibody Chemokine (C X C motif) receptor 4 antibody Chemokine CXC Motif Receptor 4 antibody CXC-R4 antibody CXCR-4 antibody CXCR4 antibody CXCR4_HUMAN antibody D2S201E antibody FB22 antibody Fusin antibody HM89 antibody HSY3RR antibody LAP 3 antibody LAP3 antibody LCR1 antibody LESTR antibody Leukocyte derived seven transmembrane domain receptor antibody Leukocyte-derived seven transmembrane domain receptor antibody Lipopolysaccharide associated protein 3 antibody Neuropeptide Y receptor Y3 antibody NPY3R antibody NPYR antibody NPYRL antibody NPYY3 antibody NPYY3R antibody Probable G protein coupled receptor lcr1 homolog antibody SDF 1 receptor antibody SDF-1 receptor antibody SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody Stromal cell derived factor 1 receptor antibody Stromal cell-derived factor 1 receptor antibody WHIM antibody WHIMS antibody

Abbreviation

CXC-R4, CXCR-4, LESTR, LAP-3, LPS-associated protein 3, SDF-1 receptor, CXCR4

Swiss Prot

P61073 Human, O08565 Rat

Cellular Locus

Cell junction. Plasma membrane. Endosome. Lysosome.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within N-terminal human CXCR4 aa.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

293, K562, Hela, HUVEC, THP-1.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:500-1:2,000 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

45 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No