Aromatase Rabbit Polyclonal Antibody

About this product

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased CYP19 activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7α-hydroxylase, CYP7A1, is the rate-limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver.

Specifications

Catalog number

ER1802-38

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ARO antibody ARO1 antibody Aromatase antibody CP19A_HUMAN antibody CPV1 antibody CYAR antibody CYP19 antibody Cyp19a1 antibody CYPXIX antibody Cytochrome P-450AROM antibody Cytochrome P450 19A1 antibody Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody Cytochrome P450, subfamily XIX (aromatization of androgens) antibody Estrogen synthase antibody Estrogen synthetase antibody Flavoprotein linked monooxygenase antibody MGC104309 antibody Microsomal monooxygenase antibody OTTHUMP00000162543 antibody OTTHUMP00000198350 antibody P 450AROM antibody

Abbreviation

CYP19A1, ARO1, CYAR, CYP19

Swiss Prot

P11511 Human, P28649 Mouse, P22443 Rat

Cellular Locus

Endoplasmic reticulum membrane, Microsome membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Aromatase aa 91-140 / 503.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

JAR cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, rat placenta tissue lysate, HepG2, SH-SY-5Y, SK-Br-3, HeLa, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:100 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No