PAX8 Rabbit Polyclonal Antibody — image 1 of 3

Product details

PAX8 Rabbit Polyclonal Antibody

Catalog number ER1802-51

Price for ER1802-51

Size / count 100 µL

About this product

The Pax family encodes transcription factors that function during embryogenesis and regulate the temporal and position-dependent differentiation of cells. Pax-8 is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. Pax-8 complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). Treatment of FRTL-5 cells with TGFβ1 decreases Pax-8 mRNA levels and Pax-8 DNA binding activity, which suppresses the expression of TG and the formation of thyrocytes. Patients who have autosomal dominant mutations of the Pax-8 gene develop thyroid dysgenesis. The Pax-8 gene produces six isoforms, A to F, that are generated by alternative splicing and differ in their carboxy-terminal regions. The Pax-8 isoforms display different DNA binding capacities and are thought to be functionally distinct. The gene which encodes Pax-8 maps to human chromosome 2q12-q14.

Specifications

Catalog number: ER1802-51
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: OTTHUMP00000158659 antibody OTTHUMP00000158660 antibody OTTHUMP00000203723 antibody OTTHUMP00000203724 antibody Paired box 8 antibody Paired box gene 8 antibody paired box homeotic gene 8 antibody Paired box protein Pax 8 antibody Paired box protein Pax-8 antibody Paired domain gene 8 antibody PAX 8 antibody PAX8 antibody PAX8_HUMAN antibody
Abbreviation: PAX8
Swiss Prot: Q06710 Human
Cellular Locus: Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within C-terminal Human PAX8.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: SKOV-3, human thyroid gland tissue, SiHa.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:400 ;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 48 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for PAX8 Rabbit Polyclonal Antibody?

The catalog number for PAX8 Rabbit Polyclonal Antibody is ER1802-51.

What sizes are available for PAX8 Rabbit Polyclonal Antibody?

PAX8 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is PAX8 Rabbit Polyclonal Antibody in stock?

PAX8 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is PAX8 Rabbit Polyclonal Antibody used for?

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.