PKM2 Rabbit Polyclonal Antibody — image 1 of 3

Product details

PKM2 Rabbit Polyclonal Antibody

Catalog number ER1802-70

Price for ER1802-70

Size / count 100 µL

About this product

In mammals, four different isoenzymes exist for pyruvate kinase. Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKM (pyruvate kinase, muscle) gene encodes the M1- and M2-type isoenzymes through alternative splicing events. Both M1- and M2-type isoforms exists as tetramers and are stimulated by fructose 1,6-bisphosphate. In addition, both isoforms exhibit thyroid hormone binding activity and may be referred to as CTHBP (cytosolic thyroid hormone-binding protein) or THBP1. The M2-type isoform also interacts with Oct-4 via its C-terminal domain, functioning to enhance Oct-4 transcriptional activity. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Specifications

Catalog number: ER1802-70
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CTHBP antibody Cytosolic thyroid hormone binding protein antibody Cytosolic thyroid hormone-binding protein antibody KPYM_HUMAN antibody MGC3932 antibody OIP 3 antibody OIP-3 antibody OIP3 antibody OPA interacting protein 3 antibody Opa-interacting protein 3 antibody p58 antibody PK muscle type antibody PK, muscle type antibody PK2 antibody PK3 antibody PKM antibody PKM2 antibody pykm antibody Pyruvate kinase 2/3 antibody Pyruvate kinase 3 antibody Pyruvate kinase isozymes M1/M2 antibody Pyruvate kinase muscle antibody Pyruvate kinase muscle isozyme antibody pyruvate kinase PKM antibody Pyruvate kinase, muscle 2 antibody TCB antibody THBP1 antibody Thyroid hormone binding protein 1 antibody Thyroid hormone binding protein cytosolic antibody Thyroid hormone-binding protein 1 antibody Tumor M2 PK antibody Tumor M2-PK antibody
Abbreviation: CTHBP, OIP-3, THBP1, PKM, OIP3, PK2, PK3, PKM2
Swiss Prot: P14618 Human
Cellular Locus: Cytoplasm. Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human PKM2 aa 370-450.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: Wild-type MDA-MB-231 whole cell lysate, SiHa cell lysate, A549 cell lysate, PC-3 cell lysate, A549, F9, PC-3M, human tonsil tissue, human thyroid carcinoma tissue, human colon cancer tissue, human breast cancer tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:400
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 58 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for PKM2 Rabbit Polyclonal Antibody?

The catalog number for PKM2 Rabbit Polyclonal Antibody is ER1802-70.

What sizes are available for PKM2 Rabbit Polyclonal Antibody?

PKM2 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is PKM2 Rabbit Polyclonal Antibody in stock?

PKM2 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is PKM2 Rabbit Polyclonal Antibody used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.