SHP-1 Rabbit Polyclonal Antibody

About this product

The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

Specifications

Catalog number

ER1802-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody

Abbreviation

PTP-1C, PTPN6, HCP, PTP1C

Swiss Prot

P29350 Human, P29351 Mouse, P81718 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide of C-terminal human SHP-1.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Mouse spleen tissue lysate, HL-60 cell lysate, rat spleen tissue lysate, HepG2, LOVO, human spleen tissue, rat spleen tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No