PTP1B Rabbit Polyclonal Antibody

About this product

The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. On the basis of sequence analysis, PTP1B (PTPase 1B) expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, a homolog of the neural adhesion molecule (NCAM). PTP1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.

Specifications

Catalog number

ER1802-83

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

PTP1B antibody Non receptor tyrosine phosphatase 1 antibody Protein phosphotyrosylphosphatase 1B antibody Protein tyrosine phosphatase 1B antibody Protein tyrosine phosphatase non receptor type 1 antibody Protein tyrosine phosphatase placental antibody Protein-tyrosine phosphatase 1B antibody PTN1_HUMAN antibody PTP 1B antibody PTP-1B antibody PTPN 1 antibody PTPN1 antibody Tyrosine protein phosphatase non receptor type 1 antibody Tyrosine-protein phosphatase non-receptor type 1 antibody

Abbreviation

PTP-1B, PTPN1, PTP1B

Swiss Prot

P18031 Human

Cellular Locus

Endoplasmic reticulum, Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human PTP1B aa 1-50 / 435.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Hela cell lysate, A431 cell lysate, HUVEC, LOVO, human tonsil tissue, human colon cancer tissue, human kidney tissue, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:200-1:500;IHC-P: 1:50-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No