KCNK1 Rabbit Polyclonal Antibody

About this product

Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium. Channel activity is modulated by activation of serotonin receptors. Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes. Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents. Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential. Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1.

Specifications

Catalog number

ER1803-39

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

DPK antibody HOHO antibody HOHO1 antibody inward rectifying potassium channel protein TWIK 1 antibody Inward rectifying potassium channel protein TWIK-1 antibody Inward rectifying potassium channel protein TWIK1 antibody K2P1 antibody K2p1.1 antibody KCNK1 antibody KCNK1_HUMAN antibody KCNO1 antibody OTTHUMP00000036029 antibody Potassium channel KCNO1 antibody Potassium channel subfamily K member 1 antibody Potassium inwardly rectifying channel subfamily K member 1 antibody TWIK 1 antibody TWIK1 antibody

Abbreviation

KCNK1, HOHO1, KCNO1, TWIK1

Swiss Prot

O00180 Human, O08581 Mouse, Q9Z2T2 Rat

Cellular Locus

Cell membrane, Recycling endosome, Synaptic cell membrane, Cytoplasmic vesicle, Perikaryon, Cell projection, dendrite, Apical cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human KCNK1 aa 40-100.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Human placenta tissue, human liver tissue, rat cerebellum tissue, human kidney tissue, mouse brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:50-1:200 ;FC: 1ug/mL

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No