LOXL2 Rabbit Polyclonal Antibody

About this product

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Specifications

Catalog number

ER1803-41

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

LOR 2 antibody LOR2 antibody LOX L2 antibody LOXL 2 antibody LOXL2 antibody LOXL2_HUMAN antibody Lysyl oxidase homolog 2 antibody Lysyl oxidase like 2 antibody Lysyl oxidase like protein 2 antibody Lysyl oxidase related 2 antibody Lysyl oxidase related protein 2 antibody Lysyl oxidase related protein WS9 14 antibody Lysyl oxidase-like protein 2 antibody Lysyl oxidase-related protein 2 antibody Lysyl oxidase-related protein WS9-14 antibody WS9 14 antibody

Abbreviation

LOXL2

Swiss Prot

Q9Y4K0 Human, P58022 Mouse, B5DF27 Rat

Cellular Locus

Endoplasmic reticulum. Nucleus. Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human LOXL2 aa 300-480.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

A431, A549, SiHa, rat testis tissue, human placenta tissue, human uterus tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:100;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 87 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No