MCU Rabbit Polyclonal Antibody — image 1 of 3

Product details

MCU Rabbit Polyclonal Antibody

Catalog number ER1803-57

Price for ER1803-57

Size / count 100 µL

About this product

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex. Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

Specifications

Catalog number: ER1803-57
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: C109A_HUMAN antibody C10orf42 antibody Calcium uniporter protein mitochondrial antibody Ccdc109a antibody Coiled-coil domain-containing protein 109A antibody HsMCU antibody Mitochondrial Calcium Uniporter antibody
Abbreviation: HsMCU, MCU, C10orf42, CCDC109A
Swiss Prot: Q8NE86 Human, Q3UMR5 Mouse
Cellular Locus: Mitochondrion.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human MCU aa 51-225 / 351.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, IF-Cell, FC
Positive Control: A549 cell lysate, HL-60 cell lysate, mouse spleen tissue lysates, mouse brain tissue lysates, HT-29, rat brain tissue, human colon tissue, mouse testis tissue, A549.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:50 ;FC: 1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 40 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for MCU Rabbit Polyclonal Antibody?

The catalog number for MCU Rabbit Polyclonal Antibody is ER1803-57.

What sizes are available for MCU Rabbit Polyclonal Antibody?

MCU Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is MCU Rabbit Polyclonal Antibody in stock?

MCU Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is MCU Rabbit Polyclonal Antibody used for?

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.