ACY-1 Rabbit Polyclonal Antibody

About this product

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene.

Specifications

Catalog number

ER1803-75

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ACY 1 antibody ACY-1 antibody Acy1 antibody ACY1_HUMAN antibody ACY1D antibody ACYLASE antibody Acylase I antibody Aminoacylase 1 antibody Aminoacylase-1 antibody EC 3.5.1.14 antibody epididymis secretory protein Li 5 antibody HEL-S-5 antibody N acyl L amino acid amidohydrolase antibody N-acyl-L-amino-acid amidohydrolase antibody OTTHUMP00000212459 antibody OTTHUMP00000212462 antibody OTTHUMP00000212463 antibody OTTHUMP00000212464 antibody OTTHUMP00000212465 antibody

Abbreviation

ACY-1, ACY1

Swiss Prot

Q03154 Human, Q99JW2 Mouse, Q6AYS7 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human ACY-1 aa 50-250.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Rat kidney tissue lysate, mouse kidney tissue lysate, HT-29, SH-SY-5Y, rat brain tissue, human liver cancer tissue, human kidney tissue, human small intestine tissue, mouse liver tissue.

Concentration

1 mg/mL

Dilution

WB:1:2,000-1:10,000;IF-Cell:1:50-1:200;IHC-P:1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No