IL-22 Rabbit Polyclonal Antibody

About this product

IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated NK and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive innate immune systems, autoimmunity and tissue regeneration. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.

Specifications

Catalog number

ER1803-85

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Cytokine Zcyto18 antibody IL 10 related T cell derived inducible factor antibody IL 21 antibody IL 22 antibody IL D110 antibody IL TIF antibody IL-10-related T-cell-derived-inducible factor antibody IL-22 antibody IL-TIF antibody IL21 antibody Il22 antibody IL22_HUMAN antibody ILD110 antibody ILTIF antibody Interleukin 10 related T cell derived inducible factor antibody interleukin 21 antibody Interleukin 22 antibody Interleukin-22 antibody MGC79382 antibody MGC79384 antibody TIFa antibody TIFIL 23 antibody TIFIL23 antibody UNQ3099/PRO10096 antibody zcyto18 antibody

Abbreviation

IL-22, IL-TIF, IL22, ILTIF, ZCYTO18

Swiss Prot

Q9GZX6 Human, Q9JJY9 Mouse,

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human IL-22 aa 34-179.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

ELISA, WB, IHC-P

Positive Control

Rat kidney tissue, human tonsil tissue, human breast cancer tissue, mouse colon tissue.

Concentration

1 mg/mL

Dilution

ELISA:1:5000-1:10,000 ;WB:1:500 ;;;;IHC-P:1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

20 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No