G-protein coupled receptor 30 Rabbit Polyclonal Antibody

About this product

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.

Specifications

Catalog number

ER1803-90

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CEPR antibody Chemoattractant receptor-like 2 antibody Chemokine receptor-like 2 antibody CMKRL2 antibody Constitutively expressed peptide like receptor antibody DRY12 antibody FEG 1 antibody FEG-1 antibody Flow-induced endothelial G protein-coupled receptor antibody Flow-induced endothelial G-protein coupled receptor 1 antibody G protein-coupled receptor 30 antibody G-protein coupled estrogen receptor 1 antibody G-protein coupled receptor 30 antibody GPCR-BR antibody Gper antibody GPER_HUMAN antibody GPER1 antibody GPR30 antibody IL8-related receptor DRY12 antibody Lergu antibody LERGU2 antibody leucine rich protein in GPR30 3'UTR antibody LYGPR antibody Lymphocyte-derived G-protein coupled receptor antibody Membrane estrogen receptor antibody mER antibody MGC99678 antibody

Abbreviation

FEG-1, LYGPR, mER, GPER1, CEPR, CMKRL2, DRY12, GPER, GPR30

Swiss Prot

Q99527 Human, Q8BMP4 Mouse, O08878 Rat

Cellular Locus

Mitochondrion,Nucleus,Endosome,Golgi apparatus,Endoplasmic reticulum,Cytoskeleton.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human G-protein coupled receptor 30 aa 236-375 / 375.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Lovo cell lysates, LoVo, SH-SY5Y, rat uterus tissue, human liver cancer tissue, human appendix tissue, human placenta tissue, mouse kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:50-1:200 ;FC: 1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No