Cytokeratin 14 Rabbit Polyclonal Antibody

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Specifications

Catalog number

ER1901-08

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CK 14 antibody CK-14 antibody ck14 antibody Cytokeratin 14 antibody Cytokeratin-14 antibody Cytokeratin14 antibody Dowling Meara antibody EBS3 antibody EBS4 antibody Epidermolysis bullosa simplex antibody K14 antibody K1C14_HUMAN antibody Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) antibody Keratin 14 antibody Keratin antibody Keratin type I cytoskeletal 14 antibody Keratin, type I cytoskeletal 14 antibody Keratin-14 antibody Keratin14 antibody Koebner antibody Krt 14 antibody Krt14 antibody NFJ antibody OTTHUMP00000164624 antibody type I cytoskeletal 14 antibody

Abbreviation

CK-14, K14, KRT14

Swiss Prot

P02533 Human, Q6IFV1 Rat

Cellular Locus

Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within Human Cytokeratin 14 aa 423-472 / 472.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

Rat skin tissue, A431, human skin tissue, human esophagus tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB:1:1,000-1:5,000 ;IHC-P:1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

53 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No