ACADL Rabbit Polyclonal Antibody — image 1 of 3

Product details

ACADL Rabbit Polyclonal Antibody

Catalog number ER1901-11

Price for ER1901-11

Size / count 100 µL

About this product

ACADL is a gene that encodes LCAD - acyl-CoA dehydrogenase, long chain - which is a member of the acyl-CoA dehydrogenase family. The acyl-CoA dehydrogenase family is primarily responsible for beta-oxidation of fatty acids within the mitochondria. LCAD dysfunction is associated with lowered fatty acid oxidation capacity and decreased heat generation. As a result, LCAD deficiency has been correlated with increased cardiac hypertrophy, pulmonary disease, and overall insulin resistance. The LCAD enzyme catalyzes most of fatty acid beta-oxidation by forming a C2-C3 trans-double bond in the fatty acid. LCAD works on long-chain fatty acids, typically between C12 and C16-acylCoA. LCAD is essential for oxidizing unsaturated fatty acids such as oleic acid, but seems redundant in the oxidation of saturated fatty acids. Fatty acid oxidation has proven to spare glucose in fasting conditions, and is also required for amino acid metabolism, which is essential for the maintenance of adequate glucose production. LCAD is regulated by a reversible acetylation mechanism by SIRT3, in which the active form of the enzyme is deacetylated, and hyperacetylation reduces the enzymatic activity.

Specifications

Catalog number: ER1901-11
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: ACAD4 antibody ACADL antibody ACADL_HUMAN antibody Acyl Coenzyme A dehydrogenase long chain antibody Acyl-CoA dehydrogenase long chain antibody FLJ94052 antibody LCAD antibody Long chain acyl CoA dehydrogenase antibody Long-chain specific acyl-CoA dehydrogenase, mitochondrial antibody
Abbreviation: ACADL
Swiss Prot: P28330 Human, P51174 Mouse
Cellular Locus: Mitochondrion matrix.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within Human ACADL aa 218-430 / 430.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: SH-SY5Y cell lysates, MG-63, human kidney tissue, human prostate cancer tissue, F9.
Concentration: 1mg/mL
Dilution: WB:1:500-1:2,000;IF-Cell:1:50-1:200;IHC-P:1:50-1:200;FC:1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 48 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for ACADL Rabbit Polyclonal Antibody?

The catalog number for ACADL Rabbit Polyclonal Antibody is ER1901-11.

What sizes are available for ACADL Rabbit Polyclonal Antibody?

ACADL Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is ACADL Rabbit Polyclonal Antibody in stock?

ACADL Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is ACADL Rabbit Polyclonal Antibody used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.