DFNA5 / GSDME Rabbit Polyclonal Antibody — image 1 of 3

Product details

DFNA5 / GSDME Rabbit Polyclonal Antibody

Catalog number ER1901-12

Price for ER1901-12

Size / count 100 µL

About this product

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.

Specifications

Catalog number: ER1901-12
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 2310037D07Rik antibody 4932441K13Rik antibody Deafness, autosomal dominant 5 antibody Deafness, autosomal dominant 5 protein antibody DFNA5 antibody DFNA5 gene antibody DFNA5_HUMAN antibody Dfna5h antibody EG14210 antibody Fin15 antibody ICERE 1 antibody ICERE-1 antibody Inversely correlated with estrogen receptor expression 1 antibody Non-syndromic hearing impairment protein 5 antibody Nonsyndromic hearing impairment protein antibody
Abbreviation: ICERE-1, GSDME-NT, GSDME-CT, GSDME, DFNA5, ICERE1
Swiss Prot: O60443 Human
Cellular Locus: Cell membrane, Cytoplasm, cytosol.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human DFNA5 / GSDME aa 1-220 / 496.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: Hela cell lysates, SiHa cell lysates, rat testis tissue, human thyroid gland tissue, human breast tissue, mouse small intestine tissue.
Concentration: 1 mg/mL
Dilution: WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 55 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for DFNA5 / GSDME Rabbit Polyclonal Antibody?

The catalog number for DFNA5 / GSDME Rabbit Polyclonal Antibody is ER1901-12.

What sizes are available for DFNA5 / GSDME Rabbit Polyclonal Antibody?

DFNA5 / GSDME Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is DFNA5 / GSDME Rabbit Polyclonal Antibody in stock?

DFNA5 / GSDME Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is DFNA5 / GSDME Rabbit Polyclonal Antibody used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.