SSRP1 Rabbit Polyclonal Antibody

About this product

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Specifications

Catalog number

ER1901-13

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Chromatin-specific transcription elongation factor 80 kDa subunit antibody Cisplatin DNA SSRP antibody Facilitates chromatin remodeling 80 kDa subunit antibody Facilitates chromatin transcription complex 80 kDa subunit antibody Facilitates chromatin transcription complex subunit SSRP1 antibody FACT 80 kDa subunit antibody FACT complex subunit SSRP1 antibody FACT80 antibody FACTp80 antibody hSSRP1 antibody Recombination signal sequence recognition protein 1 antibody Recombination signal sequence recognition protein antibody SSRP 1 antibody SSRP1 antibody SSRP1_HUMAN antibody Structure specific recognition protein 1 antibody Structure-specific recognition protein 1 antibody T160 antibody

Abbreviation

FACT 80 kDa subunit, FACTp80, hSSRP1, SSRP1, FACT80

Swiss Prot

Q08945 Human, Q08943 Mouse, Q04931 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human SSRP1 aa 192-375 / 709.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Daudi cell lysate, Hela cell lysate, 293 cell lysate, Jurkat cell lysate, rat testis tissue lysate, mouse testis tissue lysate, rat testis tissue, human skin tissue, human breast cancer tissue, mouse colon tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB:1:500-1:1000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 81 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No