CD45 Rabbit Polyclonal Antibody

About this product

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.

Specifications

Catalog number

ER1901-29

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

B220 antibody CD 45 antibody CD45 antibody CD45 antigen antibody CD45R antibody GP180 antibody L-CA antibody LCA antibody Leukocyte common antigen antibody loc antibody Ly-5 antibody LY5 antibody Ly5, homolog of antibody Lyt-4 antibody OTTHUMP00000033813 antibody OTTHUMP00000033816 antibody OTTHUMP00000033817 antibody OTTHUMP00000038574 antibody Protein tyrosine phosphatase receptor type c polypeptide antibody Protein tyrosine phosphatase, receptor type C antibody protein tyrosine phosphatase, receptor type, C antibody Protein tyrosine phosphatase, receptor type, c polypeptide antibody Ptprc antibody PTPRC_HUMAN antibody Receptor-type tyrosine-protein phosphatase C antibody T200 antibody T200 glycoprotein antibody T200 leukocyte common antigen antibody

Abbreviation

PTPRC

Swiss Prot

P08575 Human

Cellular Locus

Cell membrane, Membrane raft.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human CD45.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Jurkat cell lysates, human tonsil tissue, human spleen tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000 ;ICC/ IHC-P:1:50-1:500 ;FC:1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 147 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No