AKT3 Rabbit Polyclonal Antibody

About this product

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Specifications

Catalog number

ER1901-33

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Akt3 antibody AKT3 kinase antibody AKT3_HUMAN antibody DKFZp434N0250 antibody MPPH antibody PKB gamma antibody PKBG antibody PRKBG antibody Protein kinase Akt-3 antibody Protein Kinase AKT3 antibody Protein kinase B gamma antibody RAC gamma antibody RAC gamma serine/threonine protein kinase antibody RAC-gamma serine/threonine-protein kinase antibody RAC-PK-gamma antibody RACPK Gamma antibody Serine threonine protein kinase Akt 3 antibody Serine threonine protein kinase Akt3 antibody STK 2 antibody STK-2 antibody STK2 antibody V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) antibody V akt murine thymoma viral oncogene homolog 3 antibody V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma antibody

Abbreviation

AKT3

Swiss Prot

Q9Y243 Human, Q9WUA6 Mouse, Q63484 Rat

Cellular Locus

Nucleus, Cytoplasm, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human AKT3 aa 211-383 / 479.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

MCF7 cell lysate, Jurkat cell lysate, C6 cell lysate, rat heart tissue lysate, A549, EA.hy926, human thyroid tissue, human kidney tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000 ;IF-Cell:1:50-1:100 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 56 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No