KCNAB1 Rabbit Polyclonal Antibody

About this product

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (Probable). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6. Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity.

Specifications

Catalog number

ER1901-34

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

hKvb3 antibody hKvBeta3 antibody K (+) channel subunit beta-1 antibody KCAB1_HUMAN antibody KCNA1B antibody KCNAB1 antibody Kv-beta-1 antibody Kvb1.3 antibody Voltage-gated potassium channel beta-1 subunit antibody Voltage-gated potassium channel subunit beta-1 antibody

Abbreviation

Kcnab1

Swiss Prot

Q14722 Human, P63143 Mouse, P63144 Rat

Cellular Locus

Cell membrane, cytoplasm, membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within mouse KCNAB1 aa 36-85 / 401.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, rat cerebellum tissue lysate, EA.hy926, rat testis tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000;IF-Cell:1:50-1:100;IHC-P:1:50-1:200;FC:1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46.5 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No