KCNB1 Rabbit Polyclonal Antibody

About this product

Potassium voltage-gated channel, Shab-related subfamily, member 1, also known as KCNB1 or Kv2.1, is a protein that, in humans, is encoded by the KCNB1 gene. Potassium voltage-gated channel subfamily B member one, or simply known as KCNB1, is a delayed rectifier and voltage-gated potassium channel found throughout the body. The channel has a diverse number of functions. However, its main function, as a delayed rectifier, is to propagate current in its respective location. It is commonly expressed in the central nervous system, but may also be found in pulmonary arteries, auditory outer hair cells, stem cells, the retina, and organs such as the heart and pancreas. Modulation of K+ channel activity and expression has been found to be at the crux of many profound pathophysiological disorders in several cell types. Potassium channels are among the most diverse of all ion channels in eukaryotes. With over 100 genes coding numerous functions, many isoforms of potassium channels are present in the body, but most are divided up into two main groups: inactivating transient channels and non-inactivating delayed rectifiers. Due to the multiple varied forms, potassium delayed rectifier channels open or close in response to a myriad of signals. These include: cell depolarization or hyperpolarization, increases in intracellular calcium concentrations, neurotransmitter binding, or second messenger activity such as G-proteins or kinases.

Specifications

Catalog number

ER1901-41

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Delayed rectifier potassium channel 1 antibody Delayed rectifier potassium channel Kv2.1 antibody DRK 1 antibody DRK1 antibody h DRK1 K (+) channel antibody h-DRK1 antibody hDRK 1 antibody hDRK1 antibody KCB 1 antibody KCB1 antibody KCNB1 antibody KCNB1_HUMAN antibody KV2.1 antibody Potassium channel protein DRK1 antibody Potassium voltage gated channel shab related subfamily member 1 antibody Potassium voltage-gated channel subfamily B member 1 antibody Voltage-gated potassium channel subunit Kv2.1 antibody

Abbreviation

KCNB1

Swiss Prot

Q14721 Human, Q03717 Mouse, P15387 Rat

Cellular Locus

Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within rat KCNB1 aa 808-857 / 857.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Mouse brain tissue lysate, rat brain tissue lysate, mouse retina tissue lysates, human brain tissue, mouse brain tissue, rat brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 96 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No