P2X7 Rabbit Polyclonal Antibody — image 1 of 3

Product details

P2X7 Rabbit Polyclonal Antibody

Catalog number ER1901-50

Price for ER1901-50

Size / count 100 µL

About this product

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria. The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina. The P2X7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation. P2X7 receptors respond to BzATP more readily than ATP. ADP and AMP are weak agonists of P2X7 receptors, but a brief exposure to ATP can increase their effectiveness. Glutathione has been proposed to act as a P2X7 receptor agonist when present at milimolar levels, inducing calcium transients and GABA release from retinal cells. The P2X7 receptor current can be blocked by zinc, calcium, magnesium, and copper.

Specifications

Catalog number: ER1901-50
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: ATP receptor antibody P2rx7 antibody P2RX7_HUMAN antibody P2X purinoceptor 7 antibody P2X7 antibody P2Z receptor antibody Purinergic receptor antibody purinergic receptor P2X, ligand gated ion channel, 7 antibody
Abbreviation: P2rx7
Swiss Prot: Q99572 Human, Q9Z1M0 Mouse, Q64663 Rat
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within mouse P2X7 aa 100-200.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: Rat brain tissue lysates, EA.hy926, MCF-7, rat cerebellum tissue, human kidney tissue, mouse brain tissue, mouse kidney tissue, THP-1.
Concentration: 1 mg/mL
Dilution: WB:1:200-1:500;IF-Cell:1:50-1:100;IHC-P:1:50-1:200;FC:1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 69 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for P2X7 Rabbit Polyclonal Antibody?

The catalog number for P2X7 Rabbit Polyclonal Antibody is ER1901-50.

What sizes are available for P2X7 Rabbit Polyclonal Antibody?

P2X7 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is P2X7 Rabbit Polyclonal Antibody in stock?

P2X7 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is P2X7 Rabbit Polyclonal Antibody used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.