LGI1 Rabbit Polyclonal Antibody

About this product

Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. It may be a metastasis suppressor. The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Since its earliest discovery, the LGI1 gene has been implicated in the control of cancer metastasis and in a predisposition to epilepsy. Following genetic linkage studies placing the hereditary form of autosomal dominant partial epilepsy with auditory features (ADPEAF) on chromosome region 10q24 mutation analysis of affected members in these families demonstrated LGI1 was a major cause of the disease.

Specifications

Catalog number

ER1901-57

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ADLTE antibody ADPAEF antibody ADPEAF antibody Epitempin 1 antibody EPITEMPIN antibody Epitempin-1 antibody EPT antibody ETL1 antibody IB1099 antibody leucine rich glioma inactivated 1 antibody Leucine rich glioma-inactivated protein 1 antibody Leucine-rich glioma-inactivated protein 1 antibody LGI1 antibody LGI1_HUMAN antibody OTTHUMP00000020121 antibody OTTHUMP00000020122 antibody

Abbreviation

LGI1

Swiss Prot

O95970 Human, Q8K4Y5 Rat

Cellular Locus

Secreted, synapse.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within rat LGI1 aa 200-250.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Rat brain tissue lysates, rat spinal cord tissue, rat brain tissue, rat cerebellum tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB:1:500;IF-Cell: 1:200;IHC-P:1:50

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 64 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No