Connexin-37 Rabbit Polyclonal Antibody

About this product

Connexins (Cxs) are a family of transmembrane proteins comprising 21 members in humans that forms gap junction channels (GJCs). Connexins are divided in four groups: α, β, γ and δ. Cx37 is also named α4 since it is the fourth connexin of the alpha group that was identified. Connexins do not function as single proteins; six connexins assemble into connexons (hemi-channels), and two connexons from neighboring cells dock in the extracellular space to form a full gap junction channel. Connexins are responsible for mediating direct communication between adjacent cells by the exchange of ions and small signaling molecules and cytosolic factors1,3. Their structure consists of four transmembrane helices, two extracellular loops, a cytoplasmic loop, a cytoplasmic NH2- and COOH-termini. Connexin-37 is encoded by the GJA4 gene and is expressed in vascular endothelial cells. The protein is responsible for regulating and controlling the growth, proliferation and regeneration of the vascular endothelium by mediating the signal transduction between smooth muscle and endothelial cells. Cx37 knockout mice have a tendency for developing endarterium atheromatous plaques4. Also, a polymorphism in the gene that encodes for Cx37, is associated with increased risk for atherosclerosis and myocardial infarction1.

Specifications

Catalog number

ER1901-85

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Connexin 37 antibody Connexin-37 antibody Cx37 antibody CXA4_HUMAN antibody Gap junction alpha 4 protein antibody Gap junction alpha-4 protein antibody gap junction protein, alpha 4 37kDa (connexin 37) antibody gap junction protein, alpha 4, 37kD (connexin 37) antibody Gap junction protein, alpha 4, 37kDa antibody Gja4 antibody OTTHUMP00000004181 antibody OTTHUMP00000004182 antibody

Abbreviation

Gap junction alpha-4 protein,Connexin-37,Cx37,GJA4

Swiss Prot

P35212 Human, P28235 Mouse, Q03190 Rat

Cellular Locus

Cell junction, Cell membrane, Gap junction, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to N terminal Human Connexin-37.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

A431 cell lysate, SK-OV-3 cell lysate, 293T cell lysate, HepG2, LOVO, SKOV-3, rat brain tissue, Human small intestine tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No