CNGA4 Rabbit Polyclonal Antibody

About this product

Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. When heterologously expressed all subunits with exception of CNGA4, CNGB1 and CNGB3 can form functional homomeric channels. In olfactory sensory neurons, CNG channels which are formed by two CNGA2, one CNGA4 subunits and an isoform of CNGB1, are activated by the binding of cAMP, whose levels increase in response to the binding of odorant molecules to their respective receptors. These channels are highly expressed in retinal photoreceptors and olfactory neurons where their role has been extensively studied. CNG channels have also been detected in brain, testis and kidney although their role in these tissues has yet to be unraveled.

Specifications

Catalog number

ER1901-88

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Cyclic nucleotide-gated cation channel alpha-4 antibody Cyclic nucleotide-gated channel alpha-4 antibody CNG channel alpha-4 antibody CNG-4 antibody CNG4 antibody Cnga4 antibody Cyclic nucleotide-gated olfactory channel subunit OCNC2 antibody CNG4 antibody

Abbreviation

Cyclic nucleotide-gated cation channel alpha-4, Cyclic nucleotide-gated channel alpha-4, CNG channel alpha-4, CNG-4, CNG4. Cyclic nucleotide-gated olfactory channel subunit OCNC2, Cnga4

Swiss Prot

Q8IV77 Human, Q3UW12 Mouse, Q64359 Rat

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within rat CNGA4 aa 1-50 / 575.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

A549 cell lysate, A431 cell lysate, human brain tissue lysate, SHSY5Y cell lysate, N2A, SHSY5Y, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1000;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size 65 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No