SLC8B1 Rabbit Polyclonal Antibody

About this product

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion . Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses . Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity . Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange . In contrast to other members of the family its function is independent of K+ .

Specifications

Catalog number

ER1901-93

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

FLJ22233 antibody Na (+)/K (+)/Ca (2+) exchange protein 6 antibody Na (+)/K (+)/Ca (2+)-exchange protein 6 antibody NCKX6 antibody NCKX6_HUMAN antibody NCLX antibody Slc24a6 antibody Sodium/potassium/calcium exchanger antibody Sodium/potassium/calcium exchanger 6 antibody Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6 antibody Solute carrier family 24 member 6 antibody

Abbreviation

Mitochondrial sodium/calcium exchanger protein,SLC8B1

Swiss Prot

Q6J4K2 Human, Q925Q3 Mouse, Q6AXS0 Rat

Cellular Locus

Membrane, Mitochondrion, Mitochondrion inner membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human SLC8B1 aa 229-406 / 584.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

Mouse tonsil tissue lysates, SHSY5Y, SKOV-3, rat kidney tissue, human tonsil tissue, human pancreas tissue, Siha.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 64 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No