FOLR1 Rabbit Polyclonal Antibody

About this product

Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence. FRA can be overexpressed by a number of epithelial-derived tumors including ovarian, breast, renal, lung, colorectal, and brain. Hence antibodies to it are used in targeted therapies and diagnostic tests, e.g. farletuzumab in phase III trial for ovarian cancer. Autoantibodies to the FRA have been linked to neurodevelopmental diseases, particularly cerebral folate deficiency schizophrenia and autism spectrum disorder. Recent studies have shown that these neurodevelopmental disorders can be treated with folinic acid.

Specifications

Catalog number

ER1901-95

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

adult antibody Adult folate binding protein antibody Adult folate-binding protein antibody FBP antibody Folate Binding Protein antibody Folate Receptor 1 Adult antibody Folate receptor 1 antibody Folate Receptor 1 Precursor antibody Folate receptor adult antibody Folate receptor alpha antibody Folate receptor antibody FOLR antibody FOLR1 antibody FOLR1_HUMAN antibody FR alpha antibody FR-alpha antibody FRalpha antibody KB cells FBP antibody MOV18 antibody Ovarian cancer associated antigen antibody Ovarian tumor associated antigen antibody Ovarian tumor associated antigen MOv18 antibody Ovarian tumor-associated antigen MOv18 antibody

Abbreviation

Folate receptor alpha,FR-alpha,Adult folate-binding protein,FBP,Folate receptor 1,FOLR1,Folate receptor, adult,KB cells FBP,Ovarian tumor-associated antigen MOv18

Swiss Prot

P15328 Human, P35846 Mouse, G3V8M6 Rat

Cellular Locus

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human FOLR1 aa 25-257.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

HeLa cell lysate, JAR cell lysate, Mouse kidney tissue lysate, Rat kidney tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 30 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No