Progesterone receptor Rabbit Polyclonal Antibody — image 1 of 3

Product details

Progesterone receptor Rabbit Polyclonal Antibody

Catalog number ER1901-96

Price for ER1901-96

Size / count 100 µL

About this product

The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell.

Specifications

Catalog number: ER1901-96
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: NR3C3 antibody Nuclear receptor subfamily 3 group C member 3 antibody PGR antibody PR antibody PRA antibody PRB antibody PRGR_HUMAN antibody Progesterone receptor antibody Progestin receptor form A antibody Progestin receptor form B antibody
Abbreviation: Progesterone receptor,pr,Nuclear receptor subfamily 3 group C member 3,PGR
Swiss Prot: P06401 Human
Cellular Locus: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Progesterone receptor aa 30-250.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, FC
Positive Control: AN3CA cell lysates, A549 cell, MCF-7 cell.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2000;IF-Cell: 1:100-1:500;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size 99 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Progesterone receptor Rabbit Polyclonal Antibody?

The catalog number for Progesterone receptor Rabbit Polyclonal Antibody is ER1901-96.

What sizes are available for Progesterone receptor Rabbit Polyclonal Antibody?

Progesterone receptor Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Progesterone receptor Rabbit Polyclonal Antibody in stock?

Progesterone receptor Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Progesterone receptor Rabbit Polyclonal Antibody used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.